Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice.

As determined by the proportional bactericide method, clarithromycin had strong bactericidal activity against Mycobacterium leprae. Clarithromycin was administered to mice by gavage as 20 daily doses at dosages of 12.5 to 50 mg/kg of body weight. At a dosage of 25 mg/kg, minocycline was more active...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ji, B, Perani, E G, Grosset, J H
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1991
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1828136/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.3.579
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