Yeast chorismate mutase in the R state: Simulations of the active site

The isomerization of chorismate to prephenate by chorismate mutase in the biosynthetic pathway that forms Tyr and Phe involves C5—O (ether) bond cleavage and C1—C9 bond formation in a Claisen rearrangement. Development of negative charge on the ether oxygen, stabilized by Lys-168 and Glu-246, is inf...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ma, Jianpeng, Zheng, Xiaofeng, Schnappauf, Georg, Braus, Gerhard, Karplus, Martin, Lipscomb, William N.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843942/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14640
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