IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

The development of Th17 cells is a key event in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS). Previous studies have demonstrated that an IL-6-dependent pathway is involved in the differentiation of Th17 cells from naïve CD4-posi...

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Detalhes bibliográficos
Main Authors: Serada, Satoshi, Fujimoto, Minoru, Mihara, Masahiko, Koike, Nobuo, Ohsugi, Yoshiyuki, Nomura, Shintaro, Yoshida, Hiroto, Nishikawa, Teppei, Terabe, Fumitaka, Ohkawara, Tomoharu, Takahashi, Tsuyoshi, Ripley, Barry, Kimura, Akihiro, Kishimoto, Tadamitsu, Naka, Tetsuji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449361/
https://ncbi.nlm.nih.gov/pubmed/18577591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802218105
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