cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

We have identified unique chemical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridine)chloroplatinum(II), cis-[Pt(NH(3))(2)(py)Cl](+) or cDPCP, a coordination compound previously identified to have significant anticancer activity in a mouse tumor model...

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Autors principals: Lovejoy, Katherine S., Todd, Ryan C., Zhang, Shuzhong, McCormick, Michael S., D'Aquino, J. Alejandro, Reardon, Joyce T., Sancar, Aziz, Giacomini, Kathleen M., Lippard, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449337/
https://ncbi.nlm.nih.gov/pubmed/18579768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803441105
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