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In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate

The intercellular spaces between neurons and glia contain an amorphous, negatively charged extracellular matrix (ECM) with the potential to shape and regulate the distribution of many diffusing ions, proteins and drugs. However, little evidence exists for direct regulation of extracellular diffusion...

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Autors principals: Thorne, Robert G., Lakkaraju, Aparna, Rodriguez-Boulan, Enrique, Nicholson, Charles
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2448851/
https://ncbi.nlm.nih.gov/pubmed/18541909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711345105
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