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In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space

Diffusion within the extracellular space (ECS) of the brain is necessary for chemical signaling and for neurons and glia to access nutrients and therapeutics; however, the width of the ECS in living tissue remains unknown. We used integrative optical imaging to show that dextrans and water-soluble q...

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Autori principali: Thorne, Robert G., Nicholson, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459394/
https://ncbi.nlm.nih.gov/pubmed/16567637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509425103
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