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Spontaneous conformational change and toxin binding in α7 acetylcholine receptor: Insight into channel activation and inhibition
Nicotinic AChRs (nAChRs) represent a paradigm for ligand-gated ion channels. Despite intensive studies over many years, our understanding of the mechanisms of activation and inhibition for nAChRs is still incomplete. Here, we present molecular dynamics (MD) simulations of the α7 nAChR ligand-binding...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2448828/ https://ncbi.nlm.nih.gov/pubmed/18541920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710530105 |
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