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Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2447890/ https://ncbi.nlm.nih.gov/pubmed/18625840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711040 |
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