Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...

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Detalhes bibliográficos
Main Authors: Bonetti, Paola, Davoli, Teresa, Sironi, Cristina, Amati, Bruno, Pelicci, Pier Giuseppe, Colombo, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447890/
https://ncbi.nlm.nih.gov/pubmed/18625840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711040
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