Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bonetti, Paola, Davoli, Teresa, Sironi, Cristina, Amati, Bruno, Pelicci, Pier Giuseppe, Colombo, Emanuela
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2008
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447890/
https://ncbi.nlm.nih.gov/pubmed/18625840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711040
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