Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...

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Bibliografiska uppgifter
Huvudupphovsmän: Bonetti, Paola, Davoli, Teresa, Sironi, Cristina, Amati, Bruno, Pelicci, Pier Giuseppe, Colombo, Emanuela
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2008
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447890/
https://ncbi.nlm.nih.gov/pubmed/18625840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711040
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