Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Mutations leading to aberrant cytoplasmic localization of nucleophosmin (NPM) are the most frequent genetic alteration in acute myelogenous leukemia (AML). NPM binds the Arf tumor suppressor and protects it from degradation. The AML-associated NPM mutant (NPMmut) also binds p19Arf but is unable to p...

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Bibliographische Detailangaben
Hauptverfasser: Bonetti, Paola, Davoli, Teresa, Sironi, Cristina, Amati, Bruno, Pelicci, Pier Giuseppe, Colombo, Emanuela
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447890/
https://ncbi.nlm.nih.gov/pubmed/18625840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711040
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