A T-to-G Transversion at Nucleotide −567 Upstream of HBG2 in a GATA-1 Binding Motif Is Associated with Elevated Hemoglobin F

Increased fetal hemoglobin (Hb F; α(2)γ(2)) production in adults can ameliorate the clinical severity of sickle cell disease and β-thalassemia major. Thus, understanding the regulation of γ-globin gene expression and its silencing in adults has potential therapeutic implications. We studied a father...

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Detalhes bibliográficos
Main Authors: Chen, Zhiyi, Luo, Hong-Yuan, Basran, Raveen K., Hsu, Tien-Huei, Mang, Daniel W. H., Nuntakarn, Lalana, Rosenfield, Cathy G., Patrinos, George P., Hardison, Ross C., Steinberg, Martin H., Chui, David H. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447137/
https://ncbi.nlm.nih.gov/pubmed/18443038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00071-08
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