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Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

Human immunodeficiency virus type 1 (HIV-1) entry into the host cell involves a cascade of events and currently represents one of most attractive targets in the search for new antiviral drugs. The fusion-active gp41 core structure is a stable six-helix bundle (6-HB) folded by its trimeric N-terminal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: He, Yuxian, Cheng, Jianwei, Li, Jingjing, Qi, Zhi, Lu, Hong, Dong, Mingxin, Jiang, Shibo, Dai, Qiuyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447044/
https://ncbi.nlm.nih.gov/pubmed/18417584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00319-08
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