Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens

Broadly cross-reactive human immunodeficiency virus (HIV)-neutralizing antibodies are infrequently elicited in infected humans. The two best-characterized gp41-specific cross-reactive neutralizing human monoclonal antibodies, 4E10 and 2F5, target linear epitopes in the membrane-proximal external reg...

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Hlavní autoři: Zhang, Mei-Yun, Vu, Bang K., Choudhary, Anil, Lu, Hong, Humbert, Michael, Ong, Helena, Alam, Munir, Ruprecht, Ruth M., Quinnan, Gerald, Jiang, Shibo, Montefiori, David C., Mascola, John R., Broder, Christopher C., Haynes, Barton F., Dimitrov, Dimiter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446971/
https://ncbi.nlm.nih.gov/pubmed/18480433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00033-08
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