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Identification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine Candidate

Existing live-attenuated flavivirus vaccines (LAV) could be improved by reducing their potential to recombine with naturally circulating viruses in the field. Since the highly conserved cyclization sequences (CS) found in the termini of flavivirus genomes must be complementary to each other to suppo...

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Bibliografski detalji
Glavni autori: Suzuki, Ryosuke, Fayzulin, Rafik, Frolov, Ilya, Mason, Peter W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446964/
https://ncbi.nlm.nih.gov/pubmed/18480453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00662-08
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