Role of Aromatic Amino Acids in Receptor Binding Activity and Subunit Assembly of the Cytolethal Distending Toxin of Aggregatibacter actinomycetemcomitans

The periodontal pathogen Aggregatibacter actinomycetemcomitans produces a cytolethal distending toxin (Cdt) that inhibits the proliferation of oral epithelial cells. Structural models suggest that the CdtA and CdtC subunits of the Cdt heterotrimer form two putative lectin domains with a central groo...

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Main Authors: Cao, Linsen, Bandelac, Georges, Volgina, Alla, Korostoff, Jonathan, DiRienzo, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446717/
https://ncbi.nlm.nih.gov/pubmed/18426882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00126-08
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