Role of Aromatic Amino Acids in Receptor Binding Activity and Subunit Assembly of the Cytolethal Distending Toxin of Aggregatibacter actinomycetemcomitans

The periodontal pathogen Aggregatibacter actinomycetemcomitans produces a cytolethal distending toxin (Cdt) that inhibits the proliferation of oral epithelial cells. Structural models suggest that the CdtA and CdtC subunits of the Cdt heterotrimer form two putative lectin domains with a central groo...

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Detalhes bibliográficos
Main Authors: Cao, Linsen, Bandelac, Georges, Volgina, Alla, Korostoff, Jonathan, DiRienzo, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446717/
https://ncbi.nlm.nih.gov/pubmed/18426882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00126-08
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