Initial Delay in the Immune Response to Francisella tularensis Is Followed by Hypercytokinemia Characteristic of Severe Sepsis and Correlating with Upregulation and Release of Damage-Associated Molecular Patterns

“Francisella tularensis subsp. novicida” intranasal infection causes a rapid pneumonia in mice with mortality at 4 to 6 days with a low dose of bacteria (10(2) bacteria). The short time to death suggests that there is a failure of the innate immune response. As the neutrophil is often the first cell...

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Hlavní autoři: Mares, Chris A., Ojeda, Sandra S., Morris, Elizabeth G., Li, Qun, Teale, Judy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446713/
https://ncbi.nlm.nih.gov/pubmed/18411294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00215-08
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