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Use of Gene Dosage Effects for a Whole-Genome Screen To Identify Mycobacterium marinum Macrophage Infection Loci

We recently identified two loci, mel1 and mel2, that affect macrophage infection by Mycobacterium marinum. The ability of these loci to confer enhanced infection in trans is presumably due to gene dosage effects since their presence on plasmids increases expression from five- to eightfold. Reasoning...

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Bibliografski detalji
Glavni autori: Park, Bonggoo, Subbian, Selvakumar, El-Etr, Sahar H., Cirillo, Suat L. G., Cirillo, Jeffrey D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446711/
https://ncbi.nlm.nih.gov/pubmed/18443095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00015-08
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