The Phenolic Glycolipid of Mycobacterium tuberculosis Differentially Modulates the Early Host Cytokine Response but Does Not in Itself Confer Hypervirulence

Mycobacterium tuberculosis possesses a diversity of potential virulence factors including complex branched lipids such as the phenolic glycolipid PGL-tb. PGL-tb expression by the clinical M. tuberculosis isolate HN878 has been associated with a less efficient Th1 response and increased virulence in...

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Detalhes bibliográficos
Main Authors: Sinsimer, Daniel, Huet, Gaelle, Manca, Claudia, Tsenova, Liana, Koo, Mi-Sun, Kurepina, Natalia, Kana, Bavesh, Mathema, Barun, Marras, Salvatore A. E., Kreiswirth, Barry N., Guilhot, Christophe, Kaplan, Gilla
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446685/
https://ncbi.nlm.nih.gov/pubmed/18443098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01663-07
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