Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding α-N-acetylglucosaminidase

The Sanfilippo syndrome type B is an autosomal recessive disorder caused by mutation in the gene (NAGLU) encoding α-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. The most serious manifestations are profound mental retardation, intractable behav...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, Hong Hua, Yu, Wei-Hong, Rozengurt, Nora, Zhao, Hui-Zhi, Lyons, Karen M., Anagnostaras, Stephan, Fanselow, Michael S., Suzuki, Kunihiko, Vanier, Marie T., Neufeld, Elizabeth F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588735/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14505
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