Regulation of EP4 expression via the Sp-1 transcription factor: Inhibition of expression by anti-cancer agents

For glioblastomas, COX-2 expression is linked to poor survival. COX-2 effects are mediated by the receptors EP2 and EP4, whose regulation is poorly understood. The expression of EP4, and activation or inhibition of EP4 activity in human glioblastoma T98G cells, was found to correlate with growth on...

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Bibliographic Details
Main Authors: Kambe, Atsushi, Iguchi, Genzo, Moon, Yuseok, Kamitani, Hideki, Watanabe, Takashi, Eling, Thomas E.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443856/
https://ncbi.nlm.nih.gov/pubmed/18346464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2008.01.032
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