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Examination of Intrinsic Sulfonamide Resistance in Bacillus anthracis: A Novel Assay for Dihydropteroate Synthase

Dihydropteroate synthase (DHPS) catalyzes the formation of dihydropteroate and Mg-pyrophosphate from 6-hydroxymethyl-7,8-dihydropterin diphosphate and para-aminobenzoic acid. The Bacillus anthracis DHPS is intrinsically resistant to sulfonamides. However, using a radioassay that monitors the dihydro...

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Détails bibliographiques
Auteurs principaux: Valderas, Michelle Wright, Andi, Babak, Barrow, William W., Cook, Paul F.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443783/
https://ncbi.nlm.nih.gov/pubmed/18342015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.02.003
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