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Interplay between Cellular Methyl Metabolism and Adaptive Efflux during Oncogenic Transformation from Chronic Arsenic Exposure in Human Cells

After protracted low level arsenic exposure, the normal human prostate epithelial cell line RWPE-1 acquires a malignant phenotype with DNA hypomethylation, indicative of disrupted methyl metabolism, and shows arsenic adaptation involving glutathione overproduction and enhanced arsenic efflux. Thus,...

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Detalhes bibliográficos
Main Authors: Coppin, Jean-François, Qu, Wei, Waalkes, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443667/
https://ncbi.nlm.nih.gov/pubmed/18487201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802942200
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