Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability

Histone-modifying enzymes play a critical role in modulating chromatin dynamics. In this report we demonstrate that one of these enzymes, PR-Set7, and its corresponding histone modification, the monomethylation of histone H4 lysine 20 (H4K20), display a distinct cell cycle profile in mammalian cells...

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Detalhes bibliográficos
Main Authors: Houston, Sabrina I., McManus, Kirk J., Adams, Melissa M., Sims, Jennifer K., Carpenter, Phillip B., Hendzel, Michael J., Rice, Judd C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443654/
https://ncbi.nlm.nih.gov/pubmed/18480059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710579200
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