Increased Resistance of Complex I Mutants to Phytosphingosine-induced Programmed Cell Death

We have studied the effects of phytosphingosine (PHS) on cells of the filamentous fungus Neurospora crassa. Highly reduced viability, impairment of asexual spore germination, DNA condensation and fragmentation, and production of reactive oxygen species were observed in conidia treated with the drug,...

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Bibliographic Details
Main Authors: Castro, Ana, Lemos, Catarina, Falcão, Artur, Glass, N. Louise, Videira, Arnaldo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Metabolism and Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443650/
https://ncbi.nlm.nih.gov/pubmed/18474589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802112200
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