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Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
Parkinson disease is characterized by the accumulation of aggregated α-synuclein as the major component of the Lewy bodies. α-Synuclein accumulation in turn leads to compensatory effects that may include the up-regulation of autophagy. Another common feature of Parkinson disease (PD) is mitochondria...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060532/ https://ncbi.nlm.nih.gov/pubmed/21252228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132514 |
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