Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

Parkinson disease is characterized by the accumulation of aggregated α-synuclein as the major component of the Lewy bodies. α-Synuclein accumulation in turn leads to compensatory effects that may include the up-regulation of autophagy. Another common feature of Parkinson disease (PD) is mitochondria...

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Main Authors: Choubey, Vinay, Safiulina, Dzhamilja, Vaarmann, Annika, Cagalinec, Michal, Wareski, Przemyslaw, Kuum, Malle, Zharkovsky, Alexander, Kaasik, Allen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Bioenergetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060532/
https://ncbi.nlm.nih.gov/pubmed/21252228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132514
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