Molecular evolution of B(6 )enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B(6 )protoenzyme

BACKGROUND: The pyridoxal-5'-phosphate (PLP)-dependent or vitamin B(6)-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein families. The multiple evolutionary origin and the essential mechanistic rol...

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Hauptverfasser: Vacca, Rosa A, Giannattasio, Sergio, Capitani, Guido, Marra, Ersilia, Christen, Philipp
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443152/
https://ncbi.nlm.nih.gov/pubmed/18565210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-17
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