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Molecular evolution of B(6 )enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B(6 )protoenzyme
BACKGROUND: The pyridoxal-5'-phosphate (PLP)-dependent or vitamin B(6)-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein families. The multiple evolutionary origin and the essential mechanistic rol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443152/ https://ncbi.nlm.nih.gov/pubmed/18565210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-9-17 |
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