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The Role of the [2Fe-2S](2+) Cluster in Biotin Synthase: Mutagenesis of the Atypical Metal Ligand Arginine 260
Biotin synthase (BS) is an S-adenosylmethionine (AdoMet)-dependent radical enzyme that catalyzes the addition of sulfur to dethiobiotin. In common with other AdoMet radical enzymes, BS contains a [4Fe-4S] cluster that is coordinated by a highly conserved CxxxCxxC sequence motif and by the methionyl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442824/ https://ncbi.nlm.nih.gov/pubmed/17115711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061576p |
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