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The Role of the [2Fe-2S](2+) Cluster in Biotin Synthase: Mutagenesis of the Atypical Metal Ligand Arginine 260

Biotin synthase (BS) is an S-adenosylmethionine (AdoMet)-dependent radical enzyme that catalyzes the addition of sulfur to dethiobiotin. In common with other AdoMet radical enzymes, BS contains a [4Fe-4S] cluster that is coordinated by a highly conserved CxxxCxxC sequence motif and by the methionyl...

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Bibliografski detalji
Glavni autori: Broach, Robyn B., Jarrett, Joseph T.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442824/
https://ncbi.nlm.nih.gov/pubmed/17115711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061576p
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