ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

We have shown previously that oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, stimulate angiogenesis via induction of autocrine mediators, such as vascular endothelial growth factor (VEGF). We now address the pathways mediating up-regulation of VEGF in human endotheli...

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Bibliografske podrobnosti
Main Authors: Oskolkova, Olga V., Afonyushkin, Taras, Leitner, Alexander, von Schlieffen, Elena, Gargalovic, Peter S., Lusis, Aldons J., Binder, Bernd R., Bochkov, Valery N.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442744/
https://ncbi.nlm.nih.gov/pubmed/18451308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-112870
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