ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

We have shown previously that oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, stimulate angiogenesis via induction of autocrine mediators, such as vascular endothelial growth factor (VEGF). We now address the pathways mediating up-regulation of VEGF in human endotheli...

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Główni autorzy: Oskolkova, Olga V., Afonyushkin, Taras, Leitner, Alexander, von Schlieffen, Elena, Gargalovic, Peter S., Lusis, Aldons J., Binder, Bernd R., Bochkov, Valery N.
Format: Artigo
Język:Inglês
Wydane: American Society of Hematology 2008
Hasła przedmiotowe:
Hemostasis, Thrombosis, and Vascular Biology
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442744/
https://ncbi.nlm.nih.gov/pubmed/18451308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-112870
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