ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

We have shown previously that oxidized phospholipids (OxPLs), known to accumulate in atherosclerotic vessels, stimulate angiogenesis via induction of autocrine mediators, such as vascular endothelial growth factor (VEGF). We now address the pathways mediating up-regulation of VEGF in human endotheli...

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Detalhes bibliográficos
Main Authors: Oskolkova, Olga V., Afonyushkin, Taras, Leitner, Alexander, von Schlieffen, Elena, Gargalovic, Peter S., Lusis, Aldons J., Binder, Bernd R., Bochkov, Valery N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442744/
https://ncbi.nlm.nih.gov/pubmed/18451308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-112870
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