Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and primates. First-in-human clinical studies of recombin...

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Главные авторы: Sportès, Claude, Hakim, Frances T., Memon, Sarfraz A., Zhang, Hua, Chua, Kevin S., Brown, Margaret R., Fleisher, Thomas A., Krumlauf, Michael C., Babb, Rebecca R., Chow, Catherine K., Fry, Terry J., Engels, Julie, Buffet, Renaud, Morre, Michel, Amato, Robert J., Venzon, David J., Korngold, Robert, Pecora, Andrew, Gress, Ronald E., Mackall, Crystal L.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2008
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442646/
https://ncbi.nlm.nih.gov/pubmed/18573906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071681
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