Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching

Immunoglobulin heavy chain (IgH) class switch recombination (CSR) replaces the initially expressed IgH Cμ exons with a set of downstream IgH constant region (C(H)) exons. Individual sets of C(H) exons are flanked upstream by long (1–10-kb) repetitive switch (S) regions, with CSR involving a deletion...

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Detalles Bibliográficos
Main Authors: Zarrin, Ali A., Goff, Peter H., Senger, Kate, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2008
Assuntos:
Brief Definitive Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442634/
https://ncbi.nlm.nih.gov/pubmed/18541713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080451
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