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Antigen presentation of detergent free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein

The smaller isoform of glutamate decarboxylase (GAD65) is a major autoantigen in type 1 diabetes (TID). Its hydrophobic character requires detergent to keep the protein in solution, which complicates studies of antigen processing and presentation. In this study an attempt was made to replace deterge...

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Detalhes bibliográficos
Main Authors: Steed, Jordan, Gilliam, Lisa K., Harris, Robert A., Lernmark, Åke, Hampe, Christiane S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442559/
https://ncbi.nlm.nih.gov/pubmed/18353353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2008.02.006
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