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Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index

This work investigated the effect of ultrasonic frequency on the threshold for blood-brain barrier (BBB) disruption induced by ultrasound pulses combined with an ultrasound contrast agent. Experiments were performed in rabbits using ultrasound pulses at 2.04 MHz using sonications with peak pressure...

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Main Authors: McDannold, Nathan, Vykhodtseva, Natalia, Hynynen, Kullervo
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442477/
https://ncbi.nlm.nih.gov/pubmed/18207311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ultrasmedbio.2007.10.016
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