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Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index

This work investigated the effect of ultrasonic frequency on the threshold for blood-brain barrier (BBB) disruption induced by ultrasound pulses combined with an ultrasound contrast agent. Experiments were performed in rabbits using ultrasound pulses at 2.04 MHz using sonications with peak pressure...

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Bibliographic Details
Main Authors: McDannold, Nathan, Vykhodtseva, Natalia, Hynynen, Kullervo
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442477/
https://ncbi.nlm.nih.gov/pubmed/18207311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ultrasmedbio.2007.10.016
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