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Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

The main characteristics of cocaine addiction are compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. A current popular hypothesis is that compulsive cocaine use and cocaine relapse is due to drug-induced neuroadaptations in reward-related learnin...

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Detalhes bibliográficos
Main Authors: Thomas, M J, Kalivas, P W, Shaham, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442442/
https://ncbi.nlm.nih.gov/pubmed/18345022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.77
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