A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells

Estrogen receptor α (ERα) plays an important role in several human cancers. Most current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. Instead of the traditional approach of targeting estrogen binding to ER, we describe a strategy using a...

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Bibliografiset tiedot
Päätekijät: Mao, Chengjian, Patterson, Nicole M., Cherian, Milu T., Aninye, Irene O., Zhang, Chen, Montoya, Jamie Bonéy, Cheng, Jingwei, Putt, Karson S., Hergenrother, Paul J., Wilson, Elizabeth M., Nardulli, Ann M., Nordeen, Steven K., Shapiro, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Transcription, Chromatin, and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442351/
https://ncbi.nlm.nih.gov/pubmed/18337247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709936200
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