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Neutrophil Elastase Cleaves Laminin-332 (Laminin-5) Generating Peptides That Are Chemotactic for Neutrophils

Proteolytic processing of laminin-332 by matrix metalloproteinase (MMP)-2 and MMP-14 has been shown to yield fragments that are promigratory for epithelial cells. During acute and chronic inflammation, proteases are elaborated by neutrophils and macrophages that can degrade basement membranes. We in...

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Bibliographische Detailangaben
Hauptverfasser: Mydel, Piotr, Shipley, J. Michael, Adair-Kirk, Tracy L., Kelley, Diane G., Broekelmann, Thomas J., Mecham, Robert P., Senior, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442305/
https://ncbi.nlm.nih.gov/pubmed/18178964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706239200
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