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Order-Disorder-Order Transitions Mediate the Activation of Cholera Toxin
To intoxicate host cells, cholera toxin (CT) holotoxin must be activated. This process requires the intracellular dissociation of the enzymatic CTA1 domain from the holotoxin components CTA2 and B5, followed by subsequent interaction with the host factor ARF6-GTP. We report the first NMR-based solut...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441595/ https://ncbi.nlm.nih.gov/pubmed/18272180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.075 |
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