Src Directly Phosphorylates Bif-1 and Prevents Its Interaction with Bax and the Initiation of Anoikis

Bif-1 interacts with Bax and enhances its conformational rearrangement, resulting in apoptosis. However, the molecular mechanism governing the interaction between Bif-1 and Bax is poorly defined. Here we provide evidence that Bif-1 is phosphorylated, an event that can be repressed by apoptotic stimu...

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Bibliografiske detaljer
Main Authors: Yamaguchi, Hirohito, Woods, Nicholas T., Dorsey, Jay F., Takahashi, Yoshinori, Gjertsen, Nicole R., Yeatman, Timothy, Wu, Jie, Wang, Hong-Gang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441553/
https://ncbi.nlm.nih.gov/pubmed/18474606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709882200
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