The Role of Cardiac Troponin T Quantity and Function in Cardiac Development and Dilated Cardiomyopathy

BACKGROUND: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ra...

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Hoofdauteurs: Ahmad, Ferhaan, Banerjee, Sanjay K., Lage, Michele L., Huang, Xueyin N., Smith, Stephen H., Saba, Samir, Rager, Jennifer, Conner, David A., Janczewski, Andrzej M., Tobita, Kimimasa, Tinney, Joseph P., Moskowitz, Ivan P., Perez-Atayde, Antonio R., Keller, Bradley B., Mathier, Michael A., Shroff, Sanjeev G., Seidman, Christine E., Seidman, J. G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441440/
https://ncbi.nlm.nih.gov/pubmed/18612386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002642
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