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Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment

BACKGROUND: Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondria...

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Détails bibliographiques
Auteurs principaux: Goncalves, Sergio, Paupe, Vincent, Dassa, Emmanuel P, Rustin, Pierre
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440763/
https://ncbi.nlm.nih.gov/pubmed/18558000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2377-8-20
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