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Cation–π Interactions Stabilize the Structure of the Antimicrobial Peptide Indolicidin near Membranes: Molecular Dynamics Simulations

We implemented molecular dynamics simulations of the 13-residue antimicrobial peptide indolicidin (ILPWKWPWWPWRR-NH(2)) in dodecylphosphocholine (DPC) and sodium dodecyl sulfate (SDS) micelles. In DPC, a persistent cation–π interaction between TRP11 and ARG13 defined the structure of the peptide nea...

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Bibliografiske detaljer
Main Authors: Khandelia, Himanshu, Kaznessis, Yiannis N.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440664/
https://ncbi.nlm.nih.gov/pubmed/17201448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp064776j
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