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Prime-boost vaccination with a combination of proteosome-degradable and wild-type forms of two influenza proteins leads to augmented CTL response

Targeting viral antigens for proteosomal degradation has previously been proposed as a means for immunogenicity augmentation. However, utilization of modified unstable antigens may be insufficient for potent T-cell cross-presentation by APCs, a mechanism that requires high levels of the antigenic pr...

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Main Authors: Ilyinskii, P. O., Meriin, A. B., Gabai, V. L., Zhirnov, O. P., Thoidis, G., Shneider, A. M.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440663/
https://ncbi.nlm.nih.gov/pubmed/18400345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.02.050
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