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Differential Regulation of the Cellular Response to DNA Double-strand Breaks in G1

Double-strand breaks (DSBs) are potentially lethal DNA lesions that can be repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). We show that DSBs induced by ionizing radiation (IR) are efficiently processed for HR and bound by Rfa1 during G1, while endonuclease-indu...

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Autori principali: Barlow, Jacqueline H., Lisby, Michael, Rothstein, Rodney
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440653/
https://ncbi.nlm.nih.gov/pubmed/18406328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.01.016
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