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Protein Phosphatase-1 Inhibitor-3 Is an in Vivo Target of Caspase-3 and Participates in the Apoptotic Response
Inh3 (inhibitor-3) is a potent inhibitor of protein phosphatase-1 that selectively associates with PP1γ1 and PP1α but not the PP1β isoform. We demonstrate that Inh3 is a novel substrate for caspase-3 and is degraded in vivo during apoptosis induced by actinomycin D. Inh3 was not degraded in apoptoti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440612/ https://ncbi.nlm.nih.gov/pubmed/18450750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709735200 |
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