Inflammatory Levels of Nitric Oxide Inhibit Airway Epithelial Cell Migration by Inhibition of the Kinase ERK1/2 and Activation of Hypoxia-inducible Factor-1α

Increased synthesis of NO during airway inflammation, caused by induction of nitric-oxide synthase 2 in several lung cell types, may contribute to epithelial injury and permeability. To investigate the consequence of elevated NO production on epithelial function, we exposed cultured monolayers of hu...

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Main Authors: Bove, Peter F., Hristova, Milena, Wesley, Umadevi V., Olson, Nels, Lounsbury, Karen M., van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440600/
https://ncbi.nlm.nih.gov/pubmed/18424783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709914200
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