A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease

p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells. Multiple p120 isoforms are expressed in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1. However, only full-length p120...

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Detalhes bibliográficos
Main Authors: Yanagisawa, Masahiro, Huveldt, Deborah, Kreinest, Pamela, Lohse, Christine M., Cheville, John C., Parker, Alexander S., Copland, John A., Anastasiadis, Panos Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440599/
https://ncbi.nlm.nih.gov/pubmed/18407999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801192200
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