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Resistance of mitochondrial p53 to dominant inhibition
BACKGROUND: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization. In addition, it can be out-competed by the binding to p53 DNA recognition moti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440547/ https://ncbi.nlm.nih.gov/pubmed/18547443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-54 |
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